Abstract
Morphological revertants of the avian erythroblastosis virus (AEV)-transformed rat cell line ATla were isolated and characterized. The revertants are similar to the uninfected parental rat cell line in that they have regained an organized cytoskeleton and they are no longer capable of anchorage-independent growth. The pattern of integrated viral DNA in the revertants is indistinguishable from that of the transformed parent. However, the-revertants do not express the integrated viral genome at either the mRNA or protein level. Phenotypic reversion thus is probably due to reduced transcription of the AEV-transforming gene below a threshold necessary to induce morphological transformation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
