Abstract
Background: We investigated the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on cardiovascular structure development in children. Methods: We followed 1356 children mean aged 6.6 years for 4.5-year in Beijing, China. We assessed the association of MASLD with cardiovascular structure (cIMT and LVM) outcomes at baseline and follow-up. Results: Over follow-up, 59 children had persistent MASLD, 109 had incident MASLD (progression), 35 had normalization of liver health. Children with MASLD normalization showed a significantly lower mean development in cIMT (0.161 vs 0.188 mm) and LVM (4.5 vs 12.4 g) than children with persistent MASLD. Conclusions: The control of MASLD was associated with improved cardiovascular structure development.
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