Reversible pseudo-Pelger anomaly related to sulfisoxazole therapy.

Abstract

The Pelger-Huët anomaly of granulocytic leukocytes is a benign hereditary disorder1 characterized by poor segmentation and condensation of nuclear chromatin.2 In the heterozygous state the vast majority of nuclei are rodlike or bilobed; in the rare homozygous condition, there is a complete lack of nuclear segmentation, all the nuclei showing a round or slightly indented appearance.3 Morphologic changes resembling the Pelger-Huët anomaly (acquired pseudo-Pelger anomaly) have been described in several myeloproliferative diseases.4 This report deals with a case of acquired pseudo-Pelger anomaly in association with drug fever and rash secondary to the administration of sulfisoxazole (Gantrisin).Case ReportA 27-year-old . . .