Abstract
Saline solutions made hyperosmotic by addition of sucrose increase the discharge frequency of miniature spontaneous junctional potentials at neuromuscular junctions and sympathetic ganglia and can alter structure in both muscle and nerve. Since effects of such solutions on synaptic structure are unknown, we have investigated the influence of hyperosmolarity on function and ultrastructure in synaptic regions of isolated abdominal sympathetic ganglia of the bullfrog, Rana catesbiana.Synaptic transmission was monitored by extracellular recording of postganglionic responses to supramaximal.preganglionic stimulation (0.3 Hz). Ganglia were first equilibrated in normal frog Ringer's solution, then transferred to test solutions, and some ganglia were subsequently returned to normal Ringer's to examine functional and structural recovery.
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More From: Proceedings, annual meeting, Electron Microscopy Society of America
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