Abstract
Memantine hydrochloride is a is a reversible cholinesterase inhibitor used in the treatment of Alzheimer’s disease, low-moderate affinity, uncompetitive n-methyl-d-aspartate (NMDA) receptor antagonist, with strong voltage dependency and rapid blocking/unblocking kineticsThe present study was explore the potential of mamentine loaded nanoparticle.with varying quantity of chitosan byionotropic gelation method.The effect of chitosan quantity on the particle size was studied by varying stirring time and stirring speed. The particle morphology can be modulated by selecting the agitation speed as well as drug polymer ratio In the present study.The evaluation parameters like Zeta potential, Entrapment efficiency and Poly dispersity index,of optimized formulation CN15 was found to be 364.2±3.37, -8.46, 79.9±0.2 sand 0.283± 0.048 respectively Determination of percentage yield and loading efficiency,in vitro drug release was also found optimum en 99-100%.
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