Abstract
The effect of intravenous aminophylline on pulmonary mechanics was investigated in 31 patients with chronic obstructive lung disease. Significant decrease in pulmonary resistance and early increase in dynamic compliance were characteristic of patients with asthma and bronchitis whereas in patients with emphysema change in resistance was insignificant and increase in dynamic compliance was delayed. Patients with bronchial asthma showed greater decrease in inspiratory resistance than patients with chronic bronchitis and greater decrease in both inspiratory and expiratory resistance than patients with chronic bronchitis and emphysema. Study of changes in pulmonary mechanics after a bronchodilator might be useful in distinguishing various types of chronic obstructive lung disease.
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