Abstract
The use of enhanced-fluidity liquids in reversed-phase HPLC separations is characterized. Enhanced fluidi liquids are commonly used liquids with high proportions of low viscosity fluids, such as carbon dioxide, added. When carbon dioxide is added to the methanol-water mobile phase, substantially lower plate heights and time of analysis are achieved without losing mobile phase solvent strength. The results indicate that these improvements are caused by the combination of the increased diffusivity of the enhanced-fluidity solvents and the ability of carbon dioxide to readily break hydrogen bonds in the methanol-water mixtures.
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