Reversed-phase and normal-phase thin-layer chromatography and their application to the lipophilicity prediction of synthetic pyrethroids based on quantitative structure–retention relationships

Abstract

Synthetic pyrethroids are pesticides derived from naturally occurring pyrethrins. Nowadays, they are one of the most commonly used insecticides. Synthetic pyrethroids are applied in many areas including agriculture, veterinary medicine, households, and public health. The chromatographic properties of 7 synthetic pyrethroids with known lipophilicity have been studied by use of planar chromatography. Reversed-phase and normal-phase thin-layer chromatography approaches were applied. The main goal of this study was to evaluate retention parameters as the possible measure of the lipophilicity of synthetic pyrethroids. Upon the obtained results, it can be concluded that the best chromatographic system to predict log P is reversed-phase thin-layer chromatography and a mixture of tetrahydrofuran and water (r = 0.972). This conclusion was also confirmed by the performed principal component analysis. Furthermore, the utilization of computational descriptors, calculated by Dragon software, showed which physicochemic...