Abstract
A rapid, precise, economical and accurate HPLC method for estimation of ezetimibe in bulk and pharmaceutical formulations has been developed. The chromatographic resolution of ezetimibe was achieved using acetonitrile:0.02 M potassium dihydrogen orthophosphate buffer (72:28 v/v) as the mobile phase with UV detection at 232 nm and C8 kromasil 5 μ column. The flow rate was 1 ml/min. Results of the analysis were validated statistically and by recovery studies and were found to be satisfactory.
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