Abstract
Intracellular Ca2+ concentration [Ca2+]i and intracellular Na+ concentration [Na+]i were elevated in swine (RyR1-R615C) and rodent (RyR1-R163C) MH susceptible (MHS) compared to Wt (MHN) muscle fibers. In both MHN and MHS muscle fibers stepwise reduction of external [Na+] gradually increased [Ca2+]i, which could be prevented by removal of extracellular Ca2+ ([Ca2+]ext). Disruption of the T-system by glycerol treatment also reduced the magnitude of the [Ca2+]i elevation induced by Na+ free solution in both groups.
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