Abstract
The influenza B virus genome RNA segment 7 encodes the M1 and BM2 protein. The BM2 protein is synthesized by a coupled translational termination–reinitiation mechanism at the overlapping stop–start pentanucleotide in a bicistronic mRNA transcribed from RNA segment 7. However, features and function of this protein remain unclear. BM2 encodes 12 and 17 kDa protein, which was incorporated into virions; 17 kDa species is a phosphorylated form of the BM2 protein. The start code ATG of BM2 gene was mutated to ACC in order to close the BM2 protein expression and mutated phosphorylated site Thr (69) ACA to ATA generating defected influenza B virus with M gene mutation in order to test the function of BM2 protein.
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