Abstract
Chronic administration of triazolam (0.25 mg/kg/day, i.p.) on days 1–8 and its withdrawal produced an anxiogenic reaction in mice as assessed in the mirrored-chamber test. Daily administration of bupropion (2 or 5 mg/kg, i.p.) prior to triazolam for 8 days prevented withdrawal-induced anxiety in mice. Triazolam withdrawal also induced a significant increase in the locomotor activity of mice indicating an anxiogenic response. Daily administration of bupropion (2 or 5 mg/kg) prior to triazolam for 8 days also prevented withdrawal-induced increased locomotor activity. In conclusion, chronic administration of bupropion (2 and 5 mg/kg) exhibited a significant protection against triazolam withdrawal-induced anxiety and hyperlocomotor activity in mice. The result suggests the protective effect of bupropion in the management of triazolam withdrawal reactions.
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