Abstract
We studied the effects of CGP 35348, a centrally active blocker of GABA B receptors, on scopolamine-induced amnesia for a passive avoidance response in the mouse. Both pre-training or post-training intraperitoneal administration of the GABA B antagonist (75, 150 and 300 mg/kg i.p.) significantly reduces the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results are in agreement with previous observations indicating a role for the GABA B receptors in the modulation of memory function, and suggest a possible role of GABA B receptor antagonists as nootropic drugs.
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