Abstract
Reversal of Rocuronium-Induced Neuromuscular Block with Neostigmine in the Libyan Patients
Highlights
Acetylcholinesterase (AChE) is catalyzing the quick hydrolysis of acetylcholine (ACh) to acetate and choline
Qualitative and Quantitative Determination of Neostigmine: The qualitative determination of neostigmine was confirmed by the presence of the principle band at 261 nm of the UVvisible absorption spectrum of the four Neostigmine methlsulphate brands which is corresponding to the spectrum of the neostigmine reference standard and all spectra exhibit identical absorption spectrum
Molecular Docking Analysis: The modeling study was performed in this paper showed great interactions between neostigmine and human acetylcholinesterase
Summary
Acetylcholinesterase (AChE) is catalyzing the quick hydrolysis of acetylcholine (ACh) to acetate and choline. Rocuronium is frequently used non-depolarizing neuromuscular blocking agents (NMBAs) to facilitate tracheal intubation and affording muscle relaxation throughout surgery. Patients receiving these agents are at danger of outstanding curarization, which is a cause of postoperative pulmonary complications and might augment postoperative mortality [6,7]. Anticholinesterases may have a direct agonistic effect by increasing the release of acetylcholine from presynaptic nerve terminals [9]. Reversal of the enduring effect of rocuronium by neostigmine is a common procedure performed in the Libyan hospitals. The reversal of the continuing effect of rocuronium by neostigmine was evaluated
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