Abstract
Sir .—While doing a literature search on the drug amantadine, I came across an anecdotal Letter to the Editor of the Medical Journal of Australia by Dr Gordon White. Dr White reported treating a male infant with classic Down syndrome with graduated doses of amantadine for prevention of respiratory complications, particularly those due to A2 influenza virus. 1 Dr White claimed that during treatment with amantadine, which began when the infant was 2 weeks old and continued until age 9 months (at which time Dr White wrote his letter), the child had developed according to the accepted mental-age milestones. On days that the child was not given amantadine, there was a loss in muscle tone, increased floppiness, excessive drooling at the mouth, etc. 1 Despite this intriguing observation, there have been no further reports in the medical literature of use of amantadine in Down syndrome. However, the possibility that
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