Abstract
l-Lysine inhibition of penicillin synthesis by resting cells of Penicillium chrysogenum in a synthetic medium was confirmed. Stimulation of the rate of antibiotic formation by α-aminoadipic acid was observed in the same system. In a complex medium allowing growth of the fungus, lysine inhibition was reversed by α-amino-adipic acid or, to a lesser degree, by adipic acid. The relative concentrations of lysine and α-aminoadipic acid appear to be extremely important in the penicillin fermentation. The data suggest, that α-aminoadipic acid has a role in penicillin biosynthesis; lysine apparently interferes with this role.
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