Reversal of fibrosis in eosinophilic esophagitis: Another feather in the PPI cap?

Abstract

Eosinophilic esophagitis (EoE) is an immune-antigen-mediated disease characterized by a transmural eosinophil-predominant inflammation of the esophagus [1]. Chronic uncontrolled eosinophilic inflammation ultimately leads to remodeling and alters the structure and function of the esophagus [2,3], with dysmotility [4], esophageal rigidity [5], progressive dysphagia and food impaction and, finally, stricture formation [6]. The endoscopic signs of EoE remodeling can be obvious with fibrostenotic features such as rings and strictures that cause food impaction [7,8].