Abstract
THYROID hormone interacts with the rat liver tyrosine oxidase system in vitro and in vivo 1. The site of the inhibition proved to be at the first enzymatic step of the system, namely, tyrosine-α-ketoglutarate transaminase1,2. Canellakis and Cohen3 first demonstrated an inhibition of this enzyme by epinephrine, using the enzyme from dog liver. Since, under certain conditions, thyroxin and epinephrine are metabolically related4, it seemed likely that a demonstration of a similar action of both these hormones on the same enzyme system might provide a basis for exposing a mechanism of hormone action. Some empirical effects of epinephrine upon blood amino-acid levels are known5–7; but virtually no attempts have been made to explain these results at the molecular level.
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