Abstract
Various types of calcium channel blockers verapamil, gallopamil, devapamil, diltiazem, and nifedipine and a calmodulin inhibitor R24571 were evaluated for reversal of chloroquine(CQ) resistance of Plasmodium falciparum in an in vitro system. The results demonstrated that some of the above Ca2+ antagonists such as verapamil, gallopamil, devapamil and diltiazem were found to exert remarkable reversal activity of CQ resistance of the falciparum parasite in vitro, while the others like nifedipine and R24571 had no reversal properties of CQ resistance of the parasite. In addition, reversal activities of the CQ resistance by enantiomers of some calcium channel blockers(R-(+)-verapamil, R-(+)-gallopamil and R-(+)-devapamil), which do not bind to the calcium channel, were also observed in this study. The data strongly indicate that the mechanism of reversal of CQ resistance of falciparum malaria in vitro is independent of the calcium channel.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
