Abstract
Human skin layers serve as a barrier between the body and the environment, by preventing water loss and blocking the entry of chemicals, allergens, and microbes. Recent data showed that skin lipids are vital ‘key players’ of several functions and mechanisms performing in the skin, such as, barrier function and microbiome composition. Abnormalities in lipid composition have been observed in inflammatory cutaneous diseases with a disrupted skin barrier. This review aims to demonstrate the fundamental role of keratinocytes, sebocytes, and microbiome-derived lipids in the maintenance of the skin barrier. Furthermore, it would reveal the correlation between altered skin lipids’ composition, microbiome, and the occurrence of certain dermatological disorders such as acne vulgaris, atopic dermatitis, psoriasis, and rosacea.
Highlights
IntroductionThe skin is the largest organ of the human body with a surface area of approximately
Altered Skin Lipids Composition andThe skin is the largest organ of the human body with a surface area of approximately1.7 square meters
Atopic dermatitis (AD) is a chronic, inflammatory skin disease primarily triggered by defective skin barrier function and altered immune responses leading to clinical symptoms such as dry skin, eczema, and persistent itching
Summary
The skin is the largest organ of the human body with a surface area of approximately. It is a complex organ with many vital functions, such as protection, thermoregulation, sensation, immunity, and barrier [1]. It consists of layers, the outer layer is the epidermis, the middle layer is the dermis, and the deeper layer is the hypodermis (or subcutaneous tissue). Balanced skin lipid composition is necessary for barrier integrity and stability, antimicrobial activity, and pH maintenance. Nowadays it is widely accepted that abnormalities in skin lipid composition is associated with several diseases such as acne vulgaris, rosacea, atopic dermatitis, and psoriasis [2,3,4]. We aim to clarify the correlation between altered lipid composition and disrupted microbiome with the occurrence and severity of the above cutaneous diseases.
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