Abstract
Surface functionalization is generally accepted as one of the most useful methods for endowing better biocompatibility of the cardiovascular implants. Chondroitin sulfate (CS) is a commercial drug applied for preventing cardiovascular diseases in clinics, suggesting a potential application for functionalized coatings. Our previous work demonstrated that the CS conjugated onto the poly-dopamine (PDA)/hexanediamine (HD) co-deposited 316L stainless steel (316L SS) could endow the surface stronger multi-functions for cardiovascular implants. However, the natural CS has two subtypes, CS A and CS C, while it is still unclear which subtype makes more contribution to the surface modification of cardiovascular implants. Thus, the present study focus on comparing CS A and CS C via preparing functionalized coatings on the cardiovascular implants. Our data suggested PDA/HD-CS C coating possessed better blood compatibility and pro-endothelialization function through controlling the phenotype and distribution of macrophages, smooth muscle cells and endothelial cells in time sequence and space sequence.
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