Abstract
Islet Transplantation Pancreatic islet transplantation is a potentially promising therapy for type 1 diabetes, but poor revascularization hinders islet long-term viability. Figueiredo et al. studied the role of protein tyrosine phosphatase 1B (PTP1B) in regulating islet vascularization. Islets from PTP1B−/− mice retained more endothelial cells during in vitro culture and restored normoglycemia when transplanted into the anterior chamber of the eye in diabetic mice. Future work is needed to determine whether targeting PTP1B can improve islet transplantation in human patients. Sci. Transl. Med. 11 , eaar6294 (2019).
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