Revascularization of immature necrotic teeth with platelet-rich fibrin and blood clot

Abstract

Background: Endodontic treatment of immature permanent teeth with necrotic pulp, with or without apical pathosis, poses several clinical challenges. Regenerative endodontics is a promising alternative for the treatment of such immature necrotic permanent teeth. Aim: To assess the regenerative potential of young permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods. Settings and Design: This was an experimental, in vivo study comparing the two groups. Materials and Methods: Immature necrotic permanent teeth (n = 14) in patients who belonged to the age group of 10-12 years were selected and divided into two groups. Group 1 was treated by conventional revascularization with blood clot and Group 2 with revascularization using PRF. Follow-up was done for 6 months. Standardized radiographs were analyzed for the periradicular healing and apical closure, and clinical analysis was performed using mobility index as compared to baseline values. Statistical Analysis Used: Results were analyzed using Friedman test, Wilcoxon test, and Mann-Whitney U-test. Results: There was increased periradicular healing and apical closure at 3 months and 6 months in Group 2 (PRF) when compared to Group 1 (conventional). Conclusions: Revascularization with PRF procedure leads to better and faster healing, reduced radiolucency, enhanced apical closure, and reduction in mobility of necrotic immature teeth.