Abstract
Background: Fodogia agrestis is a medicinal plant widely for its reported antibacterial and aphrodisiac activities. Revalidation of its known antimicrobial and aphrodisiac activities holds promise for dual usage as an antibacterial and aphrodisiac agent. Objective: To validate the use of Fodogia agrestis as antibacterial and aphrodisiac agents in Kano state, Nigeria. Materials and Methods: Antibacterial activity of the ethanolic extract of the Fadogia agrestis was tested on four standard bacterial isolates at a concentration of 500µg using the agar diffusion method. The aphrodisiac activities of ethanolic extract of the plant were evaluated in male albino rats. The rats were given oral doses of 50mg/kg body weight, 100mg/kg, and 200mg/kg of extract at three-hour intervals respectively. Their mounting behaviors were evaluated. Aphrodisiac activity of the extract was compared with that of Sildinafil (Viagra). Phytochemical analysis and acute toxicity tests were done as well (LD50) Results: The ethanolic extract from Fadogia agrestis contains glycosides and carbohydrates, steroids, saponins, resins, and flavonoids Extracts of the plant resulted in a significant increase in mount frequency up to 9 attempts/15 min in albino rats at a minimum concentration of 50mg/kg. The mount activity doubled with a doubling of extract concentration. Extract of Fadogia agrestis showed similar activity with Sildenafil (Viagra). extract of Fadogia agrestis inhibited only Staphylococcus aureus and Pseudomonas aeruginosa. Conclusion antibacterial and aphrodisiac effects of Fadogia agrestis plant extract in rats are hereby revalidated. Future studies should outline the minimal inhibitory concentration and clinical significance of extract. Conditions. In line with the practice of herbal medicine in many communities all over the world, Keywords: Antibacterial and aphrodisiac property, Fadogia agrestis, Albino rats, Acute toxicity, and Viagra
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