Abstract
ObjectiveReturn-to-work (RTW) following diagnosis of infiltrative low-grade gliomas is unknown.MethodsSwedish patients with histopathologic verified WHO grade II diffuse glioma diagnosed between 2005 and 2015 were included. Data were acquired from several Swedish registries. A total of 381 patients aged 18–60 were eligible. A matched control population (n = 1,900) was acquired. Individual data on sick leave, compensations, comorbidity, and treatments assigned were assessed. Predictors were explored using multivariable logistic regression.ResultsOne year before surgery/index date, 88% of cases were working, compared to 91% of controls. The proportion of controls working remained constant, while patients had a rapid increase in sick leave approximately 6 months prior to surgery. After 1 and 2 years, respectively, 52% and 63% of the patients were working. Predictors for no RTW after 1 year were previous sick leave (odds ratio [OR] 0.92, 95% confidence interval [CI] 0.88–0.96, p < 0.001), older age (OR 0.96, 95% CI 0.94–0.99, p = 0.005), and lower functional level (OR 0.64 95% CI, 0.45–0.91 p = 0.01). Patients receiving adjuvant treatment were less likely to RTW within the first year. At 2 years, biopsy (as opposed to resection), female sex, and comorbidity were also unfavorable, while age and adjuvant treatment were no longer significant.ConclusionsApproximately half of patients RTW within the first year. Lower functional status, previous sick leave, older age, and adjuvant treatment were risk factors for no RTW at 1 year after surgery. Female sex, comorbidity, and biopsy only were also unfavorable for RTW at 2 years.
Highlights
The proportion of controls working remained constant, while patients had a rapid increase in sick leave approximately 6 months prior to surgery
Predictors for no RTW after 1 year were previous sick leave, older age, and lower functional level
Swedish Brain Tumor Registry The national Swedish Brain Tumor Registry (SBTR) is a regionally based registry of adult patients diagnosed with brain tumors carrying detailed information on tumor and patient characteristics
Summary
Swedish patients with histopathologic verified WHO grade II diffuse glioma diagnosed between 2005 and 2015 were included. Data were acquired from several Swedish registries. A matched control population (n = 1,900) was acquired. Individual data on sick leave, compensations, comorbidity, and treatments assigned were assessed. We used data from nationwide Swedish registries. Linking of registries was possible through the unique personal identification numbers for Swedish citizens. Swedish Brain Tumor Registry The national Swedish Brain Tumor Registry (SBTR) is a regionally based registry of adult patients diagnosed with brain tumors carrying detailed information on tumor and patient characteristics. The level of coverage from the different regions has varied somewhat over time. A minimum registration rate of 80% was required to be included in the analysis at any given year for each region to provide
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