Abstract
Diagnostic criteria for Rett Syndrome are proposed by the International Rett Syndrome Association and the Centers for Disease Control, Koger Center, F-37, Atlanta, GA.
Highlights
The report of macrogyria in 3 of the patients and giant astrocytes in both patients with histological studies is suggestive of a forme fruste tuberous sclerosis that might be entertained in the differential diagnosis
Female sex is not included as a necessary criterion because the possibility of undiagnosed male cases cannot be ruled out
The clinical characteristics of Rett Syndrome and differential diagnoses are listed according to stages and age at onset: 1) Early onset deceleration stage, 6-18 mos; 2) rapid "destructive" stage, 1-3 yrs; 3) pseudostationary stage, 2-10 yrs; 4) late motor deterioration stage, 10+ years
Summary
The report of macrogyria in 3 of the patients and giant astrocytes in both patients with histological studies is suggestive of a forme fruste tuberous sclerosis that might be entertained in the differential diagnosis. Evidence of intrauterine growth retardation or perinatal acquired brain damage, microcephaly at birth, identifiable metabolic, degenerative or storage diseases are listed as exclusion criteria. The clinical characteristics of Rett Syndrome and differential diagnoses are listed according to stages and age at onset: 1) Early onset deceleration stage, 6-18 mos; 2) rapid "destructive" stage, 1-3 yrs; 3) pseudostationary stage, 2-10 yrs; 4) late motor deterioration stage, 10+ years.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.