Abstract
Successful ribozyme-mediated gene therapy for HIV infection has to take into account several factors: 1. The therapeutic gene must interfere with or shut down the expression of essential viral genes. 2. This requires a vector system for gene delivery and expression in HIV-sensitive cells. 3. To bypass the high genetic variability of the HIV-1 replication process, the target sequence should be chosen in highly conserved sequences of HIV-1. These fortunately are mostly present in the essential regulatory genes (tat, rev) or sequences (PBS, U5), which are required to produce infectious viral particles ().
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