RETROSPECTIVE STUDY OF CASTLEMAN DISEASE IN A TERTIARY CARE HOSPITAL

Abstract

Introduction: Castleman Disease (CD) is a rare, heterogeneous group of lymphoproliferative disorders. Unicentric Castleman Disease (UCCD) is a localized disease, with little or no systemic symptoms. It may be an incidental radiological nding or detected while investigating for a symptomatic lymph node mass. Surgery is the primary treatment and has good long-term prognosis. Multicentric Castleman Disease (MCCD) is a more serious systemic condition, often associated with constitutional symptoms. There are various types of multicentric CD including HHV8- associated, idiopathic and a subset of cases that arise in association with POEMS syndrome. Therapy is required for most patients with multicentric CD. As evidenced, the designation Castleman disease encompasses a heterogeneous group of diseases of varied pathogenesis and require different therapies. To have an accountant of occurrence Aim: of CD in a tertiary care centre and to study the clinical and histopathological features and categorize them as unicentric and multicentric tumors. Objective: To determine the frequency and pattern of CD. This study is a retrospective analysis of 8 Materials And Methods: cases of Castleman disease over a period of 12 years from June 2010 to June 2022. All cases were uni Results: centric. One case was locally extensive. The clinical symptoms were related mostly to compression effects. 7 cases were of Hyaline vascular type and one was Plasma cell variant. CD is misdiagnosed due to absence of specic clinical symptoms. It s Conclusion: hould be included in differential diagnosis when evaluating lymph node hyperplasia. The progression from chronic antigen stimulation to reactive lymphoid hyperplasia and then to overt lymphoid neoplasia can be illustrated by the Castleman disease