Retrospective study of 125 patients with Takayasu arteritis

Abstract

Objective:To study the clinical features,image findings,therapeutic strategies,and prognosis of adult and juvenile patients with Takayasu arteritis(TA).Methods:The clinical data of 125 patients with TA were retrospectively studied.Results:There were 108 female and 17 male patients.The mean age of onset was(26.9±11.0) years and 31 patients were younger than 18 years at onset.Constitutional symptoms,pulse deficit,and elevated erythrocyte sedimentation rate(ESR) were present in 38.4%,71.2%,and 49.6% of patients,respectively.Compared with adult patients,the incidences of constitutional symptoms,pulse deficit and elevated ESR were lower in juveniles(P0.05).Angiographic findings showed that Type Ⅰ(40%),Type Ⅳ(20.8%) and Type Ⅴ(30.4%) were common,and Type Ⅱa(4.8%),Type Ⅱb(1.6%) and Type Ⅲ(2.4%) were seldom seen.Type Ⅰ was more frequently seen in adult patients than in juveniles(P0.05).Biopsy findings of 12 patients with quiescent disease showed active lesions in 7 patients.Eighty patients were followed up for a median duration of 36 months.Glucocorticoid was prescribed to 58 patients;cytotoxic agents were required for 16 of them;and remission was achieved in 57 patients.Bypass and endovascular interventional procedures were performed in 36 and 21 patients,respectively.Restenosis occurred in 34.7% of bypass procedures and 77.3% of endovascular interventional procedures.Conclusion:Diminished pulse is rarely seen in juvenile TA patients than in adults.Active vascular disorders may exist in patients with stable clinical manifestations.The incidence of restenosis is higher in endovascular interventional procedures than in bypass procedures.