RETROSPECTIVE STUDY AND CURRENT REALITIES AND POSSIBILITIES OF SURGICAL TREATMENT OF OVARIAN CANCER

Abstract

Summary. The aim of the study was to study the effect of clinical and morphological factors on diagnosis and onset of disease recurrence.
 Materials and methods. To achieve this goal, we formed a sample of postoperative samples of ovarian tumor tissue, which were divided into 3 groups: comparison group — ovarian cancer (T1-3N0M0, T1-3N0M1) (РЯ n = 261) main group 1 — borderline ovarian tumor (T1-3N0M0) (singing n = 100); the main group 2 — benign tumors of the ovaries (DOYA n = 40). The age of patients ranged from 23 to 62 years. Of these, 50 % were women of childbearing age — from 23 to 36 years (n = 26). The comparison group included 46 patients diagnosed with ovarian cancer aged 35 to 78 years. Among them, the age group from 30 to 40 years old was 14 % (n = 6). Most of the observations — 56 % (n = 24) — occurred in patients aged 40-60 years. Women over 60 made up 30 % (n = 14).
 Results and discussion. Ovarian cancer in the structure of the female genital organs malignancy is characterized by an ambiguous forecast and the highest mortality rate. The leading factors determining this phenomenon are the features of tumor metastasis. Metastasis of ovarian cancer occurs at the early stages of the disease and runs a variety of ways: contact, intraperitoneal, haemacirculatory and through the lymphatic system. Such features are determined by the topography of metastatic disease, anatomy, blood supply and lymphatic channel of the female reproductive gland. The greater omentum plays the barrier role in the development of the pathological process of the abdomen. At present poor prognosis and poor treatment outcomes require reviewing approaches to the surgical treatment of ovarian cancer. In this connection defining the features of ovarian cancer metastasis provides an opportunity to find new ways to disable malignant cells distribution.
 Conclusions. A key role in the treatment of ovarian cancer has surgery, chemotherapy, and targeted therapy. Adequate staging is important in choosing treatment tactics and assessing the prevalence of the disease. The importance of genetic and molecular studies is growing, according to the results of which it is possible to predict an increased risk of developing OC, to individualize and adjust treatment regimens.