Abstract
The in vitro activity of imipenem and several other antibacterial agents (including broad spectrum penicillins, expanded spectrum cephalosporins, and fluoroquinolones) was assessed against 130 033 clinical isolates of Gram-negative aerobic bacteria, Gram-positive aerobic bacteria, and anaerobic bacteria, collected in Germany between 1986 and 1989. Overall, 97.4% of the isolates were inhibited by an imipenem concentration of 4 mg/L. Most isolates of Xanthomonas maltophilia and Pseudomonas cepacia were resistant to imipenem between 1986 and 1989. However, when these 2 species are excluded, the frequency of resistance of the remaining isolates is < 1% each for Gram-negative, Gram-positive, and anaerobic species, indicating a level of activity of imipenem greater than that of any of the 18 comparative antibacterial agents.
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