Retrospective motion compensation for edited MR spectroscopic imaging

Abstract

Edited magnetic resonance spectroscopic imaging (MRSI) is capable of mapping the distribution of low concentration metabolites such as gamma-aminobutyric acid (GABA) or and glutathione (GSH), but is prone to subtraction artifacts due to head motion or other instabilities. In this study, a retrospective motion compensation algorithm for edited MRSI is proposed. The algorithm identifies movement-affected signals by comparing residual water and lipid peaks between different transients recorded at the same point in k-space, and either phase corrects, replaces or removes affected spectra prior to spatial Fourier transformation. The method was tested on macromolecule-unsuppressed GABA-edited spin-echo MR spectroscopic imaging data acquired from 8 healthy adults scanned at 3T. Relative to non-motion compensated data sets, the motion compensated data had significantly less subtraction artifacts across subjects. The residual choline (Cho) peak in the spectrum (which is well resolved from as a different chemical shift from GABA and is completely absent in a spectrum without subtraction artifact) was used as a metric of motion artifact severity. The normalized Cho area was 5.14 times lower with motion compensation than without motion compensation. A ‘removal-only’ version of the technique is also shown to be promising in removing motion-corrupted artifacts in a GSH-edited MRSI acquisition acquired in 1 healthy subject. This study introduces a motion compensation technique and demonstrates that retrospective compensation in k-space is possible and significantly reduces the amount of subtraction artifacts in the resulting edited spectra.