Abstract
This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2Gy per fraction for rectal or rectal wall dose-volume histogram, 3.6Gy per fraction-converted rectal dose-volume histogram, normal tissue complication probability model, and actual clinical outcomes. Carbon-ion radiation therapy was predicted to have a lower probability of rectal adverse events than intensity-modulated photon radiation therapy based on dose-volume histograms and normal tissue complication probability model. There was no difference in the clinical outcome of rectal adverse events between the two modalities compared in this study.
Highlights
Carbon-ion radiotherapy (CIRT) for the treatment of prostate cancer initially began as a clinical trial at National Institute of Radiological Science (NIRS) in 1994 [1,2]
We investigated whether CIRT or Intensity-modulated radiotherapy (IMRT) is associated with fewer rectal adverse events in prostate cancer treatment
This study retrospectively analyzed data from 152 patients obtained at Gunma University Hospital from 2010 to 2013: 76 consecutive pa tients treated by CIRT and 76 consecutive patients treated by IMRT
Summary
Carbon-ion radiotherapy (CIRT) for the treatment of prostate cancer initially began as a clinical trial at National Institute of Radiological Science (NIRS) in 1994 [1,2]. Carbon ions are heavier in mass than other particles used for radiation therapy, such as electron or proton; carbon ion beams have a smaller lateral scattering component. This results in a small divergence of the carbon ion beam. Carbon ion beams are char acterized as high-linear energy transfer (LET) beams They transfer a larger mean energy per unit length in the body than low-LET radiations such as X-ray, electron, or proton beams. The optimization process enables the delivery of a highly conformal dose to (http://creativecommons.org/licenses/by/4.0/)
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