Retrospective analysis of interventional therapy for 66 cases of hilar cholangiocarcinoma with obstructive jaundice

Abstract

Objective To study the effect of interventional therapy in patients with hilar cholangiocarcinoma complicated with obstructive jaundice and to explore the factors influencing the clinical prognosis. Methods The data of 66 cases of hilar cholangiocarcinoma complicated with obstructive jaundice from January 2014 to June 2017 were retrospectively analyzed to observe the clinical prognosis of interventional therapy. Data were analyzed using spss19.0 statistical software. Liver function index was showed as ±s, compared with t test; Univariate and multivariate analyses were performed by non-conditional Logistic regression. P<0.05 was statistically significant. Results The survival rate at 12 months after interventional therapy was 80.3%, and of which the symptoms of obstructive jaundice disappeared. Liver function indexes (TBIL, ALT, IBIL, GOT) were significantly lower after treatment (all P<0.05). Tumor stage (OR=3.034, P=0.014), degree of obstruction (OR=1.143, P=0.014), child-pugh grade of liver function (OR=3.493, P=0.014), frequency of interventional therapy (OR=1.562, P=0.014) and subsequent chemotherapy (OR=3.146, P=0.014) were independent risk factors for survival of interventional therapy (all P<0.05). Conclusion Interventional therapy can significantly improve the liver function of patients with hilar cholangiocarcinoma complicated with obstructive jaundice, and reduce the symptoms of obstructive jaundice. Key words: Bile duct neoplasms; Jaundice, obstructive; Radiology, interventional; Treatment outcome