Retrospective Analysis of Fondaparinux and Low-Molecular-Weight Heparin in the Treatment of Women With Recurrent Spontaneous Abortion.

Long Zhao,Yinghui Fu,Jinhua Fu,Lijuan Qi,Shuqin Bi,Lin Li

doi:10.3389/fendo.2021.717630

Abstract

BackgroundTo compare the clinical efficacy of fondaparinux and LMWH and provide clinical evidence for the effectiveness of fondaparinux in the treatment of recurrent spontaneous abortion caused by PTS.MethodsA retrospective analysis was conducted for 120 patients diagnosed with a recurrent spontaneous abortion caused by PTS in Qingdao Jinhua Women’s Hospital from March 2019 to April 2020. The patients were divided into two groups: 68 cases in the control group, treated with LMWH, 52 cases in the observational group, treated with fondaparinux. The pregnancy outcomes and adverse reactions between the two groups of recurrent miscarriage patients were compared.ResultsNo significant difference was detected in the general data between the two groups of patients before treatment (P>0.05). In the observational group, the R value was increased, and the α and MA values were decreased after three months of treatment compared to those before treatment (P<0.05). In the control group, the R value was increased, and the MA value was decreased after three months of treatment compared to those before treatment (P<0.05). After treatment, no significant difference was observed in the pregnancy outcome between the two groups (P>0.05). The total adverse reaction rate of the fondaparinux group was lower than that of the LMWH group (P<0.05).ConclusionsIn this study, no significant difference was detected in the pregnancy outcome between fondaparinux and LMWH in the treatment of recurrent spontaneous abortion caused by PTS, but fondaparinux had a low occurrence rate of adverse reactions and high safety.

Highlights

Recurrent spontaneous abortion (RSA) is referred to two or more consecutive pregnancy failures with the same partner [1]
prethrombotic state (PTS) is a pathological hypercoagulable state, which refers to a pathological process of dysfunction or disturbance of coagulation, anticoagulation and fibrinolysis system caused by a variety of factors, and has a variety of hematological changes that can lead to thrombosis
The present study evaluated the effects of fondaparinux and low-molecular-weight heparin (LMWH) on the pregnancy outcomes and adverse reactions in the treatment of patients with a recurrent spontaneous abortion caused by PTS, thereby assessing the efficacy of fondaparinux on the RSA caused by PTS

Summary

Introduction

Recurrent spontaneous abortion (RSA) is referred to two or more consecutive pregnancy failures with the same partner [1]. PTS is a pathological hypercoagulable state, which refers to a pathological process of dysfunction or disturbance of coagulation, anticoagulation and fibrinolysis system caused by a variety of factors, and has a variety of hematological changes that can lead to thrombosis. Some studies have shown that anticoagulation therapy with low-molecular-weight heparin (LMWH) and aspirin improve pregnancy outcomes [5, 6]. The present study evaluated the effects of fondaparinux and LMWH on the pregnancy outcomes and adverse reactions in the treatment of patients with a recurrent spontaneous abortion caused by PTS, thereby assessing the efficacy of fondaparinux on the RSA caused by PTS.

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Results

Discussion

Conclusion