Abstract
Benign pigmented skin lesions, particularly solar lentigines and seborrheic keratoses, commonly spur visits to a dermatologist...
Highlights
Benign pigmented skin lesions, solar lentigines and seborrheic keratoses, commonly spur visits to a dermatologist
Topical therapy is relatively cost-effective and primarily relies on the use of triple combination cream (TCC), which is a combination of retinoic acid, hydroquinone, and corticosteroid at fixed ratios [2]
The repeated measures analysis of variance (ANOVA) and non-parametric verification with the Friedman test indicated that the changes in the numerical values for epidermal pigmentation and melanin over time were significant (Table 2)
Summary
Solar lentigines and seborrheic keratoses, commonly spur visits to a dermatologist. Seborrheic keratoses are similar to solar lentigines but appear as thick keratin lesions in the skin. Research has indicated that solar lentigines show structural changes in the epidermis that are accompanied by increases in the expression of genetic markers associated with melanin synthesis, such as proopiomelanocortin, tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, Pmel-17, and microphthalmiaassociated transcription factor [1]. These changes in the skin are permanent and do not recover by avoiding exposure to UV light. Triple Combination Cream (TCC), which is a combination of retinoic acid, hydroquinone, and a corticosteroid at fixed ratios, is an economical option for treating common pigmented skin lesions, it can elicit some discomfort, including redness, dryness, and itching
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
