Abstract
We aimed to describe the clinical features in coronavirus disease 2019 (COVID-19) cases. We studied 134 critically ill COVID-19 cases from 30 December 2019 to 20 February 2020 in an intensive care unit (ICU) at Wuhan Jinyintan Hospital. Demographics, underlying diseases, therapy strategies and test results were collected and analysed from patients on admission, admission to the ICU and 48 h before death. The non-survivors were older (65.46 (s.d. 9.74) vs. 46.45 (s.d. 11.09)) and were more likely to have underlying diseases. The blood group distribution of the COVID-19 cases differed from that of the Han population in Wuhan, with type A being 43.85%; type B, 26.92%; type AB, 10% and type O, 19.23%. Non-survivors tend to develop more severe lymphopaenia, with higher C-reactive protein, interleukin-6, procalcitonin, D-dimer levels and gradually increased with time. The clinical manifestations were non-specific. Compared with survivors, non-survivors more likely to have organ function injury, and to receive mechanical ventilation, either invasively or noninvasively. Multiple organ failure and secondary bacterial infection in the later period is worthy of attention.
Highlights
In December 2019, a novel coronavirus emerged in Wuhan and was identified as the causal pathogen of coronavirus disease 2019 (COVID-19) [1]
The present analyses revealed the clinical characteristics of 134 cases caused by COVID-19 in China
We found that the blood group distribution of the COVID-19 patients (A: 43.85%, B: 26.92%, O: 19.23%, AB: 10%) differed from that of the Han population in Wuhan [6]
Summary
In December 2019, a novel coronavirus emerged in Wuhan and was identified as the causal pathogen of coronavirus disease 2019 (COVID-19) [1]. COVID-19 is a pandemic currently affecting more than 3 million people worldwide and the rate of infection was rapid; the case fatality rate has exceeded 7% as of early May 2020 [2]. Current studies [3, 4] have demonstrated that COVID-19 often occur in elderly men with underlying diseases. There have been few studies on the clinical characteristics of COVID-19 death cases. To understand these clinical characteristics, a retrospective analysis of clinical features in 134 critically ill COVID-19 cases in Wuhan Jinyintan Hospital was carried out
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