Abstract
8102 Background: Cancer patients (pts) develop venous thrombosis more frequently than the general population; central venous catheters (CVC) insertion is a further risk factor. In this retrospective study, we analyzed whether low doses of warfarin are useful and safe in the thrombosis prophylaxis for cancer pts with CVC. Methods: Between July 2000 and May 2003, 427 pts (median age was 57 years; range 19–81) were evaluated. One hundred fifty-six (37%) pts had hematological malignancies. During warfarin prophylaxis, 142 pts received one (33%), 224 (52%) two, and 61 (15%) three or more chemotherapy regimens respectively. One hundred fifty-five pts (36%) underwent high-dose chemotherapy (HDT) followed by peripheral-blood-stem-cell transplantation (PBSCT). Three types of CVC were used throughout the study: 233 patients (54,5%) had an external device such as Vygon catheter, 167 (39%) had an external device such as Groshong Catheter, and 27 (6,5%) had a device completely internalized such as Port-a-cath. All pts...
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