Abstract
While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China. To describe clinical features and identify difficulties in the diagnosis of pregnancy-related TB, we performed a retrospective study of 28 TB inpatients at Beijing Chest Hospital. The results were presented in terms of interquartile range (IQR) for age, and medians and percentages with respect to the categorical variables. One patient (3.6%) was immediately diagnosed; for 27 patients (96.4%), the median interval from the initial onset of symptoms to diagnosis was five weeks. Eight cases (28.6%) were microbiologically confirmed. 22 (78.6%) were pulmonary TB (PTB), while six (21.4%) were extrapulmonary TB (EPTB). In addition, eight (28.6%) were miliary TB and six (21.4%) were cerebral TB. 27 (96.4%) were cured and one (3.6%) died. 15 neonates were identified, nine of which were healthy. Two were small for the gestational age (SGA) and one was a stillbirth. Three had neonatal TB, one of which died. Nine were legal abortions and four were spontaneous abortions. Indeed, there was a substantial delay in the diagnosis of TB in the pregnant women and a high incidence of both miliary and cerebral TB was evident. With timely treatment, prognosis is positive.
Highlights
While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China
It has been estimated that, in 2011, there was many as 216,500 active TB cases in pregnant women globally[4]; the number of TB cases in pregnant women in the South-East Asia World Health Organization (WHO) Region was estimated to be 67,5004; 9,500 active TB cases in pregnant women were estimated in China, which amounts to 0.7 per 1000 pregnant women and 4.4% of global burden among pregnant women[4]
We investigated the clinical characteristics of pregnant Chinese women with TB
Summary
While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China. To describe clinical features and identify difficulties in the diagnosis of pregnancy-related TB, we performed a retrospective study of 28 TB inpatients at Beijing Chest Hospital. There was a substantial delay in the diagnosis of TB in the pregnant women and a high incidence of both miliary and cerebral TB was evident. In 2017, TB affected nearly 10 million people, 3.2 million of which were females; it was responsible for an estimated 1.6 million deaths globally[1] It is one of the main causes of death for women in their fertile years[2]. Available numbers are based on the ratio of cases of women at the reproductive age combined with the crude birth rate in a particular area[3]. The aim of the research is to explore the problems that exist in the diagnosis of TB during pregnancy, which, in turn, will promote awareness of TB diagnosis in pregnant women for clinicians
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