Retrospective analysis of 273 benign fibro osseous lesionsin the sinus and maxillofacial region

Abstract

Objective:To compare and analyze the incidence, clinical features ,imaging features, the preoperative serum alkalinosis phosphatase (ALP) and recurrence rates of osteoma, ossifying fibroma (OF), and fibrous dysplasia (FD) in sinus and maxillofacial benign fibrosis (FOLS). Method: The 273 cases of FOLS with paranasal sinus and maxillofacial region in our hospital, among which there were 153 cases of osteoma, 44 cases of OF, and 76 cases of FD, were reviewed retrospectively and were follow-up for 6 months to 5 years. The incidence, gender, age, lesion location, preoperative serum ALP levels and recurrence rate of different lesions were analyzed and compared. Result:Most Osteoma occurred in paranasal sinus (72.5%),among which the most common part was ethmoid sinus (50.3%) and followed by the frontal sinus (22.1%),the ratio of female to male was 2:1,and there were 27 cases (17.7%) accompanied by sinusitis.None of the patients relapsed. Most OF occurred in the maxillofaCIal bone (65.9%) and most of the lesions were monostotic (75.0%).For those occurred in the paranasal sinuses,the ethmoid sinus (27.3%)were the most common part than others. The ratio of femal to male was almost 1∶1 and there were 12 cases (27.3%) accompanied by sinusitis. The recurrence rate of the OF was 13.6%.Most FD occured in maxillofacial bone (64.5%) were the monostotic form(64.5%) ,and in which the most common part was the maxilla (50.0%). While,most of those occurred in the paranasal sinuses were the polyostotic ones,and sphenoid sinus (34.2%) were the most common parts.The ratio of femal to male was almost 1∶1 and there were 10 cases (13.2%) accompanied by sinusitis. 12 cases relapsed (14.5%),and there were 9 cases (75.0%) acceptted the first surgery before the age of 20.The average age of onset among Osteoma［(40.7±14.55)y］,OF［(28.0±17.9)y］ and FD［(20.32±15.2)y］ were significant different (P<0.01).The preoperative serum ALP content among Osteoma［(68.3±24.1)U/L, OF(130.1±107.0) U/L and FD were (127.7±78.7) U/L significant different(P<0.01).Nevertheless,there were no differences of the preoperative serum ALP content between the monostotic and polyostotic in OF cases［(117.2±92.6) U/L,(168.7±140.1) U/L respectively,( P>0.01)］,as well as that between FD cases［(122.2±82.9) U/L, (137.7±70.7) U/L (P>0.01)］. Conclusion:The differences of the inCIdence,the age of onset,leision location,preoperative serum ALP content and reccurence rate among Osteoma,OF and FD are statistically significant.Surgery is the most effective treatment at present.