Abstract
The 2019 novel coronavirus (2019-nCov) has caused increasing number of infected cases globally. This study was performed to analyze information regarding the transmission route and presence of viral nucleic acids on several clinical samples. Confirmed 2019-nCov-infected cases were identified in Dongyang and were treated according to guidelines for the diagnosis of 2019-nCov infection released by the National Health Commission. Information regarding the contacts that the infected people had was collected to determine whether it caused clustered cases. A series of successive nucleic acid examination of feces, oropharyngeal swabs, and sputum was also performed, and the results were analyzed. A total of 19 confirmed cases of 2019-nCov infection were identified in Dongyang, Zhejiang Province, China. Five cases showed severe symptoms, and the remaining ones showed mild manifestations. Ten cases infected from two asymptomatic individuals were clustered into two groups. Among 14 cases with consecutive nucleic acid test results, four patients showed positive results in feces after their negative conversion in oropharyngeal swabs. Asymptomatic individuals with the virus could cause 2019-nCov clustered cases, and the clustered cases may differ from sporadic cases on age and length of hospitalization. In addition, nucleic acids in feces last longer than those in oropharyngeal swabs.
Highlights
Background e 2019 novel coronavirus (2019-nCov) was first reported in December 2019. It causes pneumonia in individuals, with a mortality rate of 2.3% among confirmed cases, based on data from China [1, 2]. e virus originated from wild animals and has the ability to spread among human beings via close contact [3,4,5,6,7]
With most cases being emerged in China, the clinical characteristics of 2019-nCov infection have been analyzed and increasingly understood [8,9,10,11]. erefore, the “Diagnosis and Treatment Scheme of New Coronavirus Infected Pneumonia” guidelines, announced by the National Health Commission (NHC) of China, have been updated to its seventh version
With regard to strain 1, four family members showed respiratory symptoms and they were confirmed as 2019-nCovinfected cases through the nucleic acid test. ey did not have a history of travelling to or from Wuhan or contact with the other suspected cases, but one of their family members who came from Wuhan was asymptomatic, with a pulmonary infection confirmed by the CT scan. is asymptomatic individual tested negative to the nucleic acid detection test, three oropharyngeal swabs were collected and analyzed
Summary
Retrospective Analysis of 2019-nCov-Infected Cases in Dongyang, Southeastern China. G. E 2019 novel coronavirus (2019-nCov) has caused increasing number of infected cases globally. A total of 19 confirmed cases of 2019-nCov infection were identified in Dongyang, Zhejiang Province, China. Background e 2019 novel coronavirus (2019-nCov) was first reported in December 2019 It causes pneumonia in individuals, with a mortality rate of 2.3% among confirmed cases, based on data from China [1, 2]. As on 3 March, the 2019-nCov has caused more than 80,000 confirmed cases in China With most cases being emerged in China, the clinical characteristics of 2019-nCov infection have been analyzed and increasingly understood [8,9,10,11]. Erefore, the “Diagnosis and Treatment Scheme of New Coronavirus Infected Pneumonia” guidelines, announced by the National Health Commission (NHC) of China, have been updated to its seventh version (http://www.nhc.gov.cn/yzygj/s7653p/ 202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml) With most cases being emerged in China, the clinical characteristics of 2019-nCov infection have been analyzed and increasingly understood [8,9,10,11]. erefore, the “Diagnosis and Treatment Scheme of New Coronavirus Infected Pneumonia” guidelines, announced by the National Health Commission (NHC) of China, have been updated to its seventh version (http://www.nhc.gov.cn/yzygj/s7653p/ 202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml)
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