Abstract
Currently, leprosy control relies on the clinical diagnosis of leprosy and the subsequent administration of multidrug therapy (MDT). However, many health workers are not familiar with the cardinal signs of leprosy, particularly in low-endemic settings including Cambodia. In response, a new approach to early diagnosis was developed in the country, namely retrospective active case finding (RACF) through small mobile teams. In the frame of RACF, previously diagnosed leprosy patients are traced and their contacts screened through “drives”.According to the available records, 984 of the 1,463 (67.3%) index patients diagnosed between 2001 and 2010 and registered in the national leprosy database were successfully traced in the period 2012–2015. Migration (8.4%), death (6.7%), operational issues (1.6%) and unidentified other issues (16.0%) were the main reasons for non-traceability. A total of 17,134 contacts of traced index patients (average: 2.2 household members and 15.2 neighbors) and another 7,469 contacts of the untraced index patients could be screened. Among them, 264 new leprosy patients were diagnosed. In the same period, 1,097 patients were diagnosed through the routine passive case detection system. No change was observed in the relation between the rate at which new patients were identified and the number of years since the diagnosis of the index patient. Similar to leprosy patients diagnosed through passive case detection, the leprosy patients detected through RACF were predominantly adult males. However, the fraction of PB leprosy patients was higher among the patients diagnosed through RACF, suggesting relatively earlier diagnosis.It appears that RACF is a feasible option and effective in detecting new leprosy patients among contacts of previously registered patients. However, a well-maintained national leprosy database is essential for successful contact tracing. Hence, passive case detection in the frame of routine leprosy surveillance is a precondition for efficient RACF as the two systems are mutually enhancing. Together, the two approaches may offer an interesting option for countries with low numbers of leprosy patients but evidence of ongoing transmission. The impact on leprosy transmission could be further increased by the administration of single dose rifampicin as post-exposure prophylaxis to eligible contacts.
Highlights
To date, no biomedical tests are available to and reliably diagnose subclinical Mycobacterium leprae infections and leprosy disease (Roset Bahmanyar et al, 2016)
Leprosy control largely depends on the recognition of the cardinal signs of leprosy disease by a health worker, followed by administration of multidrug therapy (MDT) (Smith et al, 2017)
We summarize the Cambodian experience with retrospective active case finding (RACF) to amplify the efforts for leprosy control in the country
Summary
No biomedical tests are available to and reliably diagnose subclinical Mycobacterium leprae infections and leprosy disease (Roset Bahmanyar et al, 2016). Leprosy control largely depends on the recognition of the cardinal signs of leprosy disease by a health worker, followed by administration of multidrug therapy (MDT) (Smith et al, 2017). As a relatively rare disease with initially inconspicuous and painless symptoms that can be mistaken for other dermatological conditions, health workers often lack experience to recognize the cardinal signs of leprosy. Patients tend to overlook symptoms and do not seek medical attention at an early stage. Leprosy is often ignored or diagnosed late, and a considerable proportion of newly detected leprosy patients suffer from severe morbidity (Anonymous, 2015)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
