Retrograde leak point pressure for evaluating postradical prostatectomy incontinence

Abstract

Objectives To evaluate a technique of measuring the retrograde leak point pressure (RLPP) for assessing men with postradical prostatectomy stress urinary incontinence (SUI). Methods We measured RLPP in adult men by retrograde infusion of the distal urethra while simultaneously recording intraurethral pressure. The reproducibility of this test, and its dependence on urethral infusion rate, bladder volume, and anterior urethral catheter position, were evaluated. RLPP and abdominal leak point pressure (ALPP) measurements were performed in postradical prostatectomy patients. RLPP was com- pared with ALPP and with severity of incontinence determined by pad usage. Results Repeated RLPP measurements were not significantly different and did not change with bladder volume up to half capacity or with the location of the catheter in the anterior urethra. The differences between RLPP measurements with infusion rates of 2, 4, and 8 mL/min were also not significant. Twenty-seven men were evaluated 6 to 108 months after surgery. Of these, 22 (81%) demonstrated SUI. Mean RLPP in men without SUI (79.2 ± 14 cm H 2O) was significantly higher than in men with SUI (51.9 ± 13 cm H 2O, P < 0.01 ). In men with SUI, ALPP and RLPP were significantly correlated, and ALPP (49.8 ± 24 cm H 2O) was not significantly different from RLPP (51.9 ± 13 cm H 2O). Pad use and RLPP were also significantly related. Conclusions RLPP measurements are reproducible and simple to perform. The pressure at which leakage occurs is easily identifiable as the plateau pressure. RLPP correlates significantly with the lowest of multiple ALPP measurements in men with SUI. This technique represents a reliable urodynamic alternative for eval- uating men with postradical prostatectomy SUI.