Abstract
These experiments examined in Swiss-Webster mice the effects of variation in intensity of transcorneal electroshock stimulation on: (1) convulsion threshold; (2) brain seizure thresholds; and, (3) retrograde amnesia (RA) in an inhibitory avoidance task. In unanesthetized mice the current intensities required for eliciting brain seizures and RA were lower than that required for elicitation of convulsions. Further, the brain seizure and RA thresholds were comparable. Light ether anesthesia administered prior to the electroshock (ES) stimulation prevented the convulsions and significantly increased both the brain seizure and RA thresholds. The results indicate that the degree of amnesia produced by ES does not depend upon the ES current level per se, but rather upon the alteration in CNS activity produced by the ES. At ES current levels sufficient to produce RA in ether anesthetized mice the primary afterdischarge of the seizure was not followed by postictal depression. Thus, postictal depression appears not to contribute to RA.
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