Abstract
Retraction: Recombinant Human Adenovirus-p53 Injection Induced Apoptosis in Hepatocellular Carcinoma Cell Lines Mediated by p53-Fbxw7 Pathway, Which Controls c-Myc and Cyclin E.
Highlights
A member of PLOS ONE’s Animal Research Advisory Group assessed the article and the authors’ comments and confirmed that the tumor sizes reported in this article far exceed community standards for humane endpoint limits in mouse tumor studies
The advisor noted that the tumor results present a significant animal welfare and ethical concern
XZ, ZZ, CL, JZ, JG, YY, QL either could not be reached or did not respond directly
Summary
The authors confirmed that in some cases tumors exceeded 20 mm in diameter. They provided general information about health monitoring and endpoint guidance at their institution, and noted that animal health was monitored every three days with increased monitoring of clinical signs and symptoms for animals bearing tumors > 1.5 cm in diameter.
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