Retraction Note: Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin-dependent protein kinase II and Ca2+/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice

Jing Shi,Jinzhou Tian,Xuekai Zhang,Jingnian Ni,Long Yin,Ting Li,Pengwen Wang,Yongyan Wang,Mingqing Wei

doi:10.1186/s12906-021-03331-0

Abstract

Background Synaptic dysfunction is one of the pathological characteristics of Alzheimer's disease (AD), which is directly related to the progressive decline of cognitive function. CaMKII and CaN have been found to play important roles in memory processes and synaptic transmission. So present study aimed to elucidate relationships between CaMKII, CaN and cognitive decline in APPV717I mice, and to reveal whether the cognitive improving effects of GAPT is conducted through rebalance CaMKII and CaN.

Highlights

Jing Shi1†, Xuekai Zhang1†, Long Yin1, Mingqing Wei1, Jingnian Ni1, Ting Li1, Pengwen Wang2, Jinzhou Tian1* and Yongyan Wang3
Concerns were raised with a number of figures, :
Figure 1: the panels for Control, APP+D, APP+Gl and APP+Gh appear to be identical to the panels for Control, APP+D, APP+Gl and APP of Fig. 1 [2]

Summary

Introduction

Jing Shi1†, Xuekai Zhang1†, Long Yin1, Mingqing Wei1, Jingnian Ni1, Ting Li1, Pengwen Wang2, Jinzhou Tian1* and Yongyan Wang3. The Editor has retracted this article [1].

Results

Conclusion