RETRACTED: Two Cu(II) and Co(II) complexes: Magnetic properties and protective activity on burn disease by regulating the proliferation capability of mutated fibroblasts

Abstract

Through the reaction of transition metal nitrates and two organic ligands, two novel coordination polymers, namely, [Cu 5 (μ 3 -OH) 2 (OPBI) 2 (PA) 4 ] n ( 1 ) and {[Co(OPBI) (PA)]·H 2 O} n ( 2 ), were synthesized by solvothermal reactions between phthalic acid (H 2 PA) and the ligand 1,1'-(oxybis (4,1-phenylene))bis (1H-imidazole) with a V shape in a solvent system consisting of water/ N , N -dimethylformamide (H 2 O/DMF). Magnetic measurements for compounds 1 and 2 indicated that antiferromagnetic coupling occurred between consecutive metal ions. For the treatment of burn disease, serial biological experiments were performed for a biological activity evaluation, followed by a mechanism exploration. Cell counting kit-8 assay was conducted to measure the proliferation capability of mutated fibroblasts after compound treatment. Real-time reverse transcription–polymerase chain reaction was implemented, and the expression levels of miRNA-29 in the migration-mutated fibroblasts were measured. The cytotoxicity of the compounds was also determined. • Two coordination polymers were synthesized. • The magnetic measurements reflected antiferromagnetic coupling between the metal centers. • Biological experiments were performed on their protective role against the burn patients.