RETRACTED: Two Co(II) coordination polymers: Magnetic properties and treatment activity on cochlear ischemia reperfusion injury (CIRI) by reducing the inflammatory response

Abstract

In the current study, under conditions of solvothermal reaction, two coordination polymers (CPs), namelcy, {[Co(TZMB)(1,4-bipb)(H 2 O)]·H 2 O} n (1) and {[Co 2 (TZMB) 2 (H 2 O)(DMA)]·DMA} n (2), have been obtained with or without using the pyridine ancillary linker 1,4-bis(pyrid-4-yl)benzene (4-bipb) via utilizing Y-type N-heterocyclic carboxylic acid 4,4′-(1 H -1,2,4-triazol-1-yl)methylene-bis(benzoic acid) (H 2 TZMB). From the magnetic researches, the antiferromagnetic coupling between contiguous metal ions exists in compounds 1 and 2 . The treatment effect of compounds 1 and 2 against the cochlear ischemia reperfusion injury (CIRI) was assessed and the related mechanism was explored at the same time. Firstly, the ELISA detection was conducted to determine the influence of the new compounds on the releasing of inflammatory cytokines by the inner ear endothelium. Next, the relative expression levels of genes related with ROS production in the inner ear endothelium was assessed by the real time RT-PCR detection.