RETRACTED: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concern was raised about the reliability of the images shown in Figure 1, and the Western blots in Figures 6C and 8E, which appear to contain similar features to those found in other publications, as detailed here: https://pubpeer.com/publications/5E5DF69C11DAD50FBE63CD4F95990F; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Additional concerns were raised over the provenance of the flow cytometry data in Figure 10C, that appear to contain repeating features. Furthermore, the myocardial infarct images in Figure 5A appear to actually show brain slices. Independent analysis also identified additional suspected image duplications within Figures 3A and 4. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.