RETRACTED: Development of two Cu(II) and Cd(II) coordination complexes based on mixed-ligand approach and application of their nanostructures as potential anti-breast cancer agents

Abstract

Abstract We report herein the fabrication and structural characterization of two new coordination complexes [Cu3(μ3-O)(pz)3(Hpz)(Hpdc)(H2O)2](H2O)4 (1, H2pdc = pyridine-3,5-dicarboxylic acid, Hpz = pyrazol) and [Cd(phen)(bdc)](H2O) (2, phen = 1,10-phenanthroline, H2bdc = 1,2- acidic benzenedicarboxylic) through the application of acidic carboxylic and the N-containing linkers as the co-ligands. The molecular arrangement for the constructed CPs were probed by the structural solution and refinement based on the singe crystal X-ray data and their phase purities was confirmed via a comparison between the simulated profile from the crystal data with the measured profile using the powder X-ray diffraction. Furthermore, an ultrasonic treatment method was used to produce the nano particles of CPs 1 and 2 with good water dispersibility and framework integrality. Moreover, the in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method were administered on the breast cancer cell line BT474 with rising aggregations of the nanostructures 1 and 2, the cell apoptosis and ROS production level was also performed on BT474 cell line. This study suggested both nanostructures 1 and 2 have promising anticancer properties.